Alzheimer’s diseaseĪ study published in the journal Neurobiology of Aging concluded that acetyl-L-carnitine may help people with Alzheimer’s disease. The authors found that patients with peripheral arterial disease were able to walk comfortably for longer times and distances after using PLC. The pain usually occurs in the feet, calves, thighs, hips or buttocks, depending on where the artery damage or narrowing occurs. It tends to affect the blood vessels in the legs, but it can affect the arms too. Intermittent claudication can lead to pain when walking or running, because damage or narrowing of an artery leads to poor blood supply. Intermittent claudicationįindings published in the journal Thrombosis Research looked at the efficacy, safety and tolerability of propionyl-L-carnitine (PLC) given to patients with a condition known as intermittent claudication. They believe carnitine may reduce symptoms of fatigue in patients with chronic diseases. “Combinations of these supplements can reduce significantly the fatigue and other symptoms associated with chronic disease and can naturally restore mitochondrial function, even in long-term patients with intractable fatigue.” Research published in Alternative Therapies In Health And Medicine suggests that combinations of supplements, including carnitine, might help improve mitochondrial function. Most chronic diseases lead to a loss of mitochondrial function that can result in fatigue and other symptoms. Fatigue and other symptoms of chronic disease ![]() Black, cell and molecular physiologist at the Vascular Biology Center at the Medical College of Georgia at Georgia Regents University. However, it did not lead to a fall in the development of heart failure or a repeat myocardial infarction (MI).Ĭarnitine may also normalize the type of blood vessel dysfunction that happens with congenital heart defects, according to Dr. In 2013, a review and meta-analysis linked L-carnitine with a 27 percent reduction in all-cause mortality, and notably, a 65 percent drop in ventricular arrhythmias and a 40 percent fall in the development of angina. The findings were published in Drugs Under Experimental and Clinical Research. Angina and heart problemsįor some time, studies have suggested that carnitine may help treat the symptoms of angina if used alongside conventional treatment. One study found that ALC is as effective as a conventional treatment, methylcobalamin (MC), in treating diabetic peripheral neuropathy.Īnother investigation, involving 19 patients, found that ALC did not change the frequency or severity of the condition. One review study has stated that acetyl-L-carnitine (ALC) had a moderate effect on reducing pain, but the evidence is still conflicting, and more research is needed. Health conditions that carnitine may be used to treat include heart failure or heart attack, angina, and diabetic neuropathy. People who lack carnitine may need to take supplements or eat specially enriched foods.Ĭarnitine is said to have many therapeutic properties that may be useful in treating a range of conditions and illnesses.Īs an antioxidant, carnitine fights off harmful free radicals, which cause severe damage to cells. Cancer and aging reduce carnitine levels. If it happens as a result of other metabolic diseases, this is secondary carnitine deficiency. ![]() To treat it, the physician will prescribe pharmacological doses of carnitine, to correct the problems of cardiomyopathy and muscle weakness. The symptoms gradually worsen from infancy to early adulthood. ![]() ![]() weak muscles in the hips, shoulders upper arms, legs, neck, and jaw muscles.progressive cardiomyopathy, or heart muscle disease.This deficiency causes problems with processing food. Primary systemic carnitine deficiency can happen when the protein that is responsible for bringing carnitine into cells undergoes a genetic change. However, genetic or medical reasons can cause some people produce too little. The liver and kidney usually produce enough carnitine in the human body, so topping up with food or supplements is not necessary.
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